Drugs & Vitamins

Active Ingredients: Chlorpheniramine Maleate, Hydrocodone, and Phenylephrine
Other Names: Cytuss HC Solution, ED-Tuss HC Syrup, Histinex HC Syrup, Hydro PC II Syrup, Mintuss HC Syrup, Mintuss HD Syrup, Mintuss MS Syrup, Poly-Tussin HD Syrup, Poly-Tussin Syrup, Relasin-HC Syrup, Rindal HD Plus Syrup, Rindal HD Syrup, Z-Cof HC Syrup
Rx Status: Available by prescription only
Generic Available: Yes
Product Images & Descriptions:

What is/are Z-Cof HC Syrup? (Back to top)
CHLORPHENIRAMINE; HYDROCODONE; PHENYLEPHRINE is a cough and cold medicine. It helps to relieve a runny nose, sneezing, watery eyes, and cough. It also helps to reduce congestion or stuffy nose. This medicine is used to treat the symptoms of upper respiratory tract infections. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• asthma
• chronic cough
• diabetes
• difficulty passing urine
• heart disease
• high blood pressure
• peripheral vascular disease
• phenylketonuria
• an unusual or allergic reaction to Chlorpheniramine; Hydrocodone; Phenylephrine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Shake well before using. If this medicine upsets your stomach, take it with food or milk . Use a specially marked spoon or container to measure your medicine. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply. This medicine is not approved for use in children less than 6 years old.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
• medicines for weight loss
• procarbazine
• some medicines for cold, cough or allergy
• some medicines for migraine headaches
• stimulants

• any alcohol-containing product
• barbiturates like phenobarbital
• heart medicines
• medicines for depression, anxiety, or psychotic disturbances
• medicines for sleep
• phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
• some medicines for pain
• some medicines used during surgery

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• change in vision
• chest pain, tightness
• cold, clammy skin
• confusion, anxiety, fear
• difficulty passing urine
• fainting
• fast or irregular heartbeat
• high or low blood pressure
• slow or troubled breathing

• constipation
• dry eyes
• dry mouth
• headache
• nausea, vomiting
• stomach upset

This list may not describe all possible side effects.

What should I watch for while using this medicine? (Back to top)
Tell your doctor or health care professional if your symptoms do not improve in 1 week. If you also have a high fever, skin rash, continuing headache, or sore throat, see your doctor. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

The medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call
your doctor or health care professional.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Where should I keep this medicine? (Back to top)
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:April 03, 2008

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